Describe the pathophysiology of Hodgkin lymphoma.
Case Study A
Hodgkin disease
J.R., age 32 years old, noticing lump on the side of his neck a few months ago. The lump is relatively large, painless, and not tender to the touch. A few days ago he experienced some difficulty swallowing as if there was something putting pressure on his esophagus. He has also notice unexplained weight loss, fever, night sweats, and general fatigue over the past few weeks. A visit to the physician produced lab results showing a marked decrease in the lymphocyte count as well as the presence of a giant cell in the tissue of a biopsied lymph node, subsequently confirmed as a Reed-Sternberg cell. The lab results confirmed Hodgkin lymphoma.
- Describe the pathophysiology of Hodgkin lymphoma.
- Outline the conditions of the disease at each of the four stages as defined by the Ann Arbor staging system.
- List some of the differences between Hodgkin and non-Hodgkin lymphoma.
- List the methods currently available to treat this disease.
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