Serotonin types and subtypes (i.e. 5-HT1A, 5-HT1B, 5-HT4, and 5-HT7) are thought to have a role in the pathophysiology of depression and antidepressant response, according to study. 

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Serotonin types and subtypes (i.e. 5-HT1A, 5-HT1B, 5-HT4, and 5-HT7) are thought to have a role in the pathophysiology of depression and antidepressant response, according to study.
Through a negative feedback mechanism, activation of 5-HT1A autoreceptors reduces the firing rate of raphe nuclei neurons, resulting in reduced 5-HT release. Mouse studies reveal that particular modification of 5-HT1A autoreceptor levels on raphe nuclei neurons during distinct developmental windows might modify anxiety behavior in adulthood, suggesting that they are linked to the genesis of anxiety behavior.

 

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